The GUTPHOS Study

• Research type

  Research Study

• Full title

  Prospective, multicentre study to validate the GastroIntestinal Dysfunction Score (GIDS) and describe prevalence, outcomes, and management of phosphate disorders in intensive care patients

• IRAS ID

  333874

• Contact name

  Ramprasad Matsa

• Contact email

  ramprasad.matsa@uhnm.nhs.uk

• Sponsor organisation

  University Hospitals of North Midlands (UHNM)

• Duration of Study in the UK

  0 years, 6 months, 28 days

• Research summary

  The Study contains two parts:

  Part A
  Patients admitted to the Intensive Care Unit (ICU) develop multiple organ dysfunction. It is important to predict the outcome (prognostication) of such patient to inform further care. Currently, there are scoring systems (eg. SOFA score) that can relatively predict such outcomes; however, they don’t include gastrointestinal dysfunction (failure of the bowel function) as a part of their scoring although we are aware that such gastrointestinal dysfunction affects majority of the patient in ICU.

  The Gastrointestinal Dysfunction Score (GIDS) has been recently developed as a five-grade score (0-4) for the assessment of bowel function. A small study performed to assess whether GIDS score can predict the outcome of ICU patients showed that it can independently predict 28- and 90-day mortality when added to the total SOFA score. Currently, we need a large study to prospectively validate GIDS score. The presence of a validated score would allow its use in further interventional studies that are currently hindered by the lack of a measurement tool. This part of the study aims to validate the GIDS score in a multicentre cohort of adult patients admitted to ICU.

  Part B
  Patients admitted to ICU have phosphate (Pi) abnormalities (important chemical in the blood that helps to maintain vital activities of metabolism and enzyme function). Such abnormalities and their management have not been studied prospectively in such patients. Hence, there is also no clear answer on when to treat such Pi abnormalities. This study will facilitate detecting relevant patient groups for which phosphate abnormalities have predictive value and could provide clinical guidance in management.
  In this part of the study, we aim to identify the prevalence, management practices, and outcomes of Pi abnormalities during the first week of ICU admission.

• REC name

  Social Care REC

• REC reference

  24/IEC08/0016

• Date of REC Opinion

  8 May 2024

• REC opinion

  Unfavourable Opinion