The Gut Microbiota in the Pathophysiology of Exercise-Induced Asthma 2
Research type
Research Study
Full title
The Effects of HOST-DM059 Prebiotic Supplementation on Gut Bacterial Metabolites, and Markers of Systemic Inflammation in Adults with and without Hyperpnoea-Induced Bronchoconstriction: A Double-Blind, Placebo-Controlled, Crossover Trial.
IRAS ID
233556
Contact name
Paul/PAL Lester
Contact email
Sponsor organisation
Nottingham Trent University
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 1 months, 0 days
Research summary
Brief Title
Does prebiotic supplementation reduce the severity of asthma through gut bacteria dependent improvements in immune function?
Summary
The ‘good’ gut bacteria play a vital role in supporting our immune system. A reduced amount of good bacteria may lead to the development of asthma. Research has shown that prebiotic supplementation may reduce the severity of asthma. However, the mechanisms responsible for reductions in the severity of asthma require further investigation. Prebiotics are carbohydrates able to support the growth and development of good bacteria. Increasing the number/activity of good bacteria may help to improve immune function, leading to a reduction in airway inflammation. However, knowledge of the relationships between the gut bacteria and immune function in asthma is limited. Exploring the role of the gut bacteria in asthma may lead to the development of new complimentary therapies focused on dietary adjustments that could be combined with existing treatments to improve the management of asthma.
Participants aged 18-50, male or female who meet the study criteria will be asked to attend Nottingham Trent University on six occasions over 12-weeks, for 10-12 hours in total. Visit one will be an initial consultation, visit two will be a familiarisation, and visits 3-6 will consist of the main experimental trials. During visits 3-6 participants will complete a 10-week nutritional intervention, consisting of two, four-week supplementation phases, separated by a 2-week washout period. Participants will be asked to consume a prebiotic during one supplementation phase, and a placebo during the other supplementation phase. During visits 3-6 participants will complete a questionnaire to assess asthma control, and a scale to monitor medication/nutritional supplement adherence. Participants will complete an in-depth assessment of their asthma, and will be asked to provide a blood sample, and two urine samples during each experimental trial.
Funding has been provided by the Sport Science Department at NTU, Imperial College London, and Clasado Biosciences/Host Therabiomics.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
17/EM/0369
Date of REC Opinion
7 Nov 2017
REC opinion
Further Information Favourable Opinion