The Gut Microbiome as a Predictor of Sleeve Gastrectomy Outcomes
Research type
Research Study
Full title
The Gut Microbiome as a Predictor of Sleeve Gastrectomy Induced Metabolic, Inflammatory and Satiety Outcomes
IRAS ID
301905
Contact name
Derek Renshaw
Contact email
Sponsor organisation
Coventry University
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Background:
Bariatric surgery, unlike other obesity treatments, induces long-term sustained weight-loss and reduces metabolic, inflammatory and satiety biomarkers of obesity. Increasingly Sleeve Gastrectomy, a form of bariatric surgery, is becoming the new ‘gold standard’ due to its simplicity, low complication rates and comparable outcomes in ameliorating obesity, compared to other bariatric surgeries. Recently, studies have reported an involvement of the gut microbiome in promoting weight-loss and improved metabolic and inflammatory status and feeding behaviour. Indeed, obese subjects show a dysregulated gut microbiome in comparison to leaner individuals. Sleeve Gastrectomy is alters gut microbiome composition and function due to its induced changes to feeding behaviour, food transit times and distal gut pH levels. Therefore, it is hypothesised Sleeve Gastrectomy-induced changes to the gut microbiome could contribute to observed metabolic, inflammatory and satiety improvements and sustained weight-loss post-surgery.Aims:
The study aim is to develop our understanding of the relationship between Sleeve Gastrectomy and its associated metabolic, inflammatory and satiety improvements, with changes in gut microbiome composition and function.Recruitment:
The study will be mentioned to potentially eligible patients at University Hospital Coventry and Warwickshire weight management clinic by their direct care team. Those showing interest will be provided with study information and explained study purpose. Patients will have 2-weeks to read through the study information. If interested, patients are invited to contact the principal investigator/ member of the research team. They will be encouraged to ask research team members any questions they have about the study. If they are then happy to participate, they will be invited to provide informed signed consent. After obtaining consent, patients will be screened for eligibility and a baseline visit will be agreed.REC name
West Midlands - Solihull Research Ethics Committee
REC reference
22/WM/0002
Date of REC Opinion
11 Mar 2022
REC opinion
Further Information Favourable Opinion