The Genomic Basis of Inflammatory Skin Disease
Research type
Research Study
Full title
The Genomic Basis of Inflammatory Skin Disease on the Island of Ireland
IRAS ID
281690
Contact name
Tony Bjourson
Contact email
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
Conservative reports estimate ~30% of the global population suffer with a skin disease at any given time and this figure represents a significant global health burden. Inflammatory skin diseases are associated with impaired quality of life through discomfort and/or disfigurement and various severe co-morbidities. The cause of these inflammatory skin diseases is a complex interplay between genetic and environmental factors, but this remains poorly understood, emphasising the need for immediate and in-depth investigation.
In this study, we will conduct the research by collecting blood samples (containing our genetic material – DNA, RNA and proteins), a lifestyle questionnaire and relevant medical information from fully-consented individuals with one of the following inflammatory skin conditions: acne vulgaris, atopic dermatitis, chronic spontaneous urticaria, hidradenitis suppurativa, or plaque psoriasis. Our genetic material is like an instruction manual containing the information needed to make, run and repair each person. In some cases, changes in our genetic material can lead to health problems.
This genomics study has tremendous potential to translate to health improvement for future patients. Specifically, the findings from this study may be used to better diagnose, predict progression and tailor treatment based on a person’s genetic makeup. It may also lead to the identification of new drug targets for the development of novel therapeutics.
REC name
HSC REC B
REC reference
20/NI/0150
Date of REC Opinion
4 Dec 2020
REC opinion
Further Information Favourable Opinion