The genetic factors for stroke in children with sickle cell disease
Research type
Research Study
Full title
Whole Exome Sequencing of very young patients with sickle cell disease to investigate genetic factors that influence the occurrence of overt ischaemic stroke
IRAS ID
216889
Contact name
David Rees
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Children with sickle cell anaemia are at increased risk of developing strokes. The majority of strokes occur between 2 and 7 years of age with a high rate of recurrence after the first episode. There appears to be a familial predisposition to stroke, where a child with sickle cell anaemia has an increased risk of stroke if they have a sibling who has suffered an overt stroke. This suggests that there may be genetic risk factors. We aim to identify genetic modifiers of stroke risk by only recruiting children who have had a stroke, or a scan predicting that they are high risk of stroke, prior to the age of 4 years. We will be using a technique that sequences all the coding regions of the human genome each individual's entire genetic make up (whole exome sequencing) and comparing this to genetic information from children with sickle cell anaemia who have no clinical risk factors for stroke.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
17/SC/0603
Date of REC Opinion
23 Feb 2018
REC opinion
Further Information Favourable Opinion