The EXPECT Study
Research type
Research Study
Full title
Exploring Predictors of IVF Success: The Role of Thromboelastography. A Prospective Observational Study - The EXPECT Study
IRAS ID
246840
Contact name
Raj Rai
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Despite improved understanding of early pregnancy development, transfer of “good” quality embryos and optimization of factors that are known to influence pregnancy rates, we still have an incomplete understanding of why many IVF embryos fail to implant or progress.
Research amongst women who suffer multiple miscarriages has highlighted the importance of the blood clotting system in implantation of the embryo. Abnormalities in this system are associated with pregnancy loss.
We will assess for changes in whole blood haemostasis at different stages of the IVF cycle and their impact on IVF outcomes. Thromboelastrography (TEG), a blood test that takes a snapshot picture of the dynamic interplay between blood clotting and the clot-breakdown systems, will be used for this purpose.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/1032
Date of REC Opinion
14 Jun 2018
REC opinion
Further Information Favourable Opinion