The evaluation of the pathophysiology of Varicose veins in pregnancy
Research type
Research Study
Full title
The evaluation of the pathophysiology of Varicose veins in pregnancy.
IRAS ID
277754
Contact name
Mohammad Aslam
Contact email
Sponsor organisation
Imperial College London & Imperial College Healthcare NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Varicose veins (VV) are the early sign of Chronic venous insufficiency (CVI) which are characterised by abnormal tortuosity and dilatation of superficial veins of lower limb extremities. Factors for the development of VV exist in literature. However, the exact mechanism remains unclear. The prevelence of VV are greater in women compared to men and also higher in pregnant women compared to non-pregnant women which make pregnant women at higher risk of developing VV. Furthermore, complications of VV have negative impacts on patients’ quality of life and health care budget. Therefore, better understanding of the cause of VV can contribute in better quality of life to the patient and provide valuable insights to help in reducing health care cost. The present study will investigate the contribution of both mechanical and chemical factors in pregnant women by taking blood samples for genomic testing, using Duplex ultrasound, vector flow imaging, limb volume assessment using Truncated cone tool, assessment of iliac vein compression using Photoplethymography (PPG) technique, hormonal blood test and assessing patient’s quality of life using Aberdeen Varicose Veins Questionnaire (AVVQ).
REC name
North of Scotland Research Ethics Committee 1
REC reference
21/NS/0052
Date of REC Opinion
17 May 2021
REC opinion
Further Information Favourable Opinion