The EndoEpi-CRT study

• Research type

  Research Study

• Full title

  Optimum deployment of left ventricular endocardial pacing site in cardiac resynchronization therapy: the EndoEpi-CRT study

• IRAS ID

  202321

• Contact name

  Francisco Leyva

• Contact email

  francisco.leyva@uhb.nhs.uk

• Sponsor organisation

  University Birmingham NHS Trust

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Patients with heart failure and an incoordinate left ventricular activation and contraction have a high risk of heart failure hospitalization and cardiac mortality beside their highly symptomatic state. CRT has shown to improve symptoms, need for hospitalisation and mortality. Clinical response to Cardiac Resynchronisation Therapy (CRT) remains sub-optimal in some patients. CRT pacing is currently delivered to the left ventricular epicardium (the outer side of the heart chamber). Left ventricular endocardial pacing is expected to be better than epicardial stimulation, because it take less time to activate the left ventricle endocardially. This study will compare left ventricular contractile force and left ventricular electrical activation between endocardial and epicardial pacing at the same cardiac location.

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  17/EM/0153

• Date of REC Opinion

  11 May 2017

• REC opinion

  Favourable Opinion