The effects of Prebiotic Supplementation on Asthma 2
Research type
Research Study
Full title
The effects of Prebiotic Supplementation on Quality of Life, Control of Asthma, and Markers of Systemic Inflammation in Adults with Asthma. A Double-Blind, Placebo-Controlled, Crossover Trial.
IRAS ID
253339
Contact name
Jacob/JJ Jayaratnasingam
Contact email
Sponsor organisation
Nottingham Trent University
ISRCTN Number
ISRCTN11358769
Duration of Study in the UK
2 years, 9 months, 1 days
Research summary
This study will investigate how prebiotic supplementation affects asthma, by observing changes in quality of life, use of current medication and systemic inflammation. Prebiotics are a carbohydrate that feeds the ‘good bacteria’ in the gut, or Probiotics. These bacteria have an important role in regulating our immune system and a reduced number/activity of these ‘good bacteria’ may lead to the development of asthma or increased severity of asthma. This study aims to increase our understanding of how the gut bacteria may contribute to the development of asthma and results may lead to a better understanding of the mechanistic characteristics of asthma; helping to develop new strategies, based on dietary changes, to assist with asthma management.
The study will be conducted on Nottingham Trent University, Clifton campus, in the sports and exercise science laboratories. The trial is 9 weeks long (two 3-week interventions, both placebo, and supplement, with a 2-week washout-period. ), and participants will visit a total of 5 times over this time period. The study involves taking of blood samples on 4 out of 5 visits, quality of life surveys, medication adherence, resting pulmonary function, 24-hour food recall and 4-day nutrition diary.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
19/EM/0088
Date of REC Opinion
10 Jun 2019
REC opinion
Further Information Favourable Opinion