The effects of hyperglycaemia on the response to acute exercise (v2)
Research type
Research Study
Full title
The effects of hyperglycaemia on the response to acute exercise
IRAS ID
202409
Contact name
Steven Carter
Contact email
Sponsor organisation
University of Birmingham
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 4 months, 31 days
Research summary
Type 2 diabetes is characterised by chronically elevated blood glucose levels (i.e. hyperglycaemia). Exercise effectively improves blood glucose control in individuals at risk of and with type 2 diabetes (Church et al. 2010; van Dijk et al. 2012; Karstoft et al. 2013), and is therefore prescribed to prevent and treat this disease. However, even within well-controlled studies, the effectiveness of exercise is extremely variable (Boule et al. 2005; Solomon et al. 2013), with evidence demonstrating smaller benefits in individuals with high pre-training blood glucose levels (e.g. diabetic patients) (Malin & Kirwan, 2012; Solomon et al. 2013; Knudsen et al. 2015). That said, the mechanisms explaining these findings are unknown. Furthermore, fluctuating glucose levels reportedly elevates the risk of developing several hyperglycaemia-related complications to a greater extent than stable high glucose levels (Esposito et al. 2002; Ceriello et al. 2008). However, the impact of the pattern of hyperglycaemia upon exercise-induced adaptations in glycaemic control remains to be established.\n\nGiven the aforementioned gaps in existing knowledge, investigating the potential mechanisms by which high blood glucose (of differing patterns) contributes to blunted improvements in glycaemic control following a single bout of exercise will improve our understanding of the metabolic non-responder, and thus will inform the development of future optimised and individualised approaches to using exercise for the improvement of glycaemic control. \n\nAccordingly, we aim to determine whether acute exposure to experimental high blood glucose impairs the exercise-induced adaptations in insulin secretion and glucose tolerance in healthy individuals, and whether the pattern of hyperglycaemia plays a role. \n
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
16/WM/0242
Date of REC Opinion
2 Jun 2016
REC opinion
Further Information Favourable Opinion