The effect of whey protein on glycaemia and appetite in T2D
Research type
Research Study
Full title
The acute and 24-h glycaemic and appetite responses to ingestion of whey protein/hydrolysed whey protein at meal times in type II diabetic individuals.
IRAS ID
173229
Contact name
Daniel J West
Contact email
Sponsor organisation
Northumbria University
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Rationale and Aims: People with type-II diabetes are characterised by the inability to adequately secrete insulin following eating carbohydrates. However, protein provides an insulin-stimulating effect similar to that of healthy individuals. Consuming a protein, such as whey protein, with a carbohydrate meal can significantly reduce blood glucose excursions, protecting type II diabetics from the risks of cardiovascular disease and diabetic complications. Therefore, our study will aim to objectively measure the postprandial blood glucose and appetite responses following the ingestion of whey protein. The findings from this study will potentially provide a useful tool to help refine strategies for tightly controlled blood glucose concentrations in primary care where dietary intervention is the first stage in type II diabetes treatment, and ultimately may lead to a reduction in diabetes related complications and risk of cardiovascular diseases in type II diabetic patients.
Methods. Patients will complete three trials; Whey Protein, Whey Protein Hydolysate, and placebo (water), separated by 7 days apart. On each visit, patients will ingest an experimental supplement (i.e. either whey, hydro, or placebo), and immediately after, consume a breakfast meal within 15 minutes. Participants will then remain rested during 3 h of blood sampling (5, 10, 15, 30, 45, 60, 90, 120, 150, and 180 minutes) and visual analogue scales (VAS). Following the 3 h period, the same supplement will again be ingested, and immediately after, the lunch meal will be consumed within 15 minutes. Participants will again remain rested during 3 h of blood sampling and VAS scales until the trial is completed. Venous blood sampling will be achieved via the use on an 18-gauge cannula. Capillary blood sampling will be achieved via standard finger-prick methodology. Blood samples collected will be analysed to capture the time-course changes in blood glucose, blood fats, and appetite-regulating hormones.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
15/NE/0119
Date of REC Opinion
19 May 2015
REC opinion
Further Information Favourable Opinion