The effect of the systemic inflammatory response on glycaemic markers
Research type
Research Study
Full title
The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on circulating glycaemic markers
IRAS ID
167490
Contact name
Rousseau Gama
Contact email
Duration of Study in the UK
0 years, 1 months, 1 days
Research summary
Does the inflammatory response resulting from elective orthopaedic surgery affect measures of blood sugar control?
HbA1c is a measure of blood sugar levels over a twelve week period and is an accepted test for diagnosing type 2 diabetes. Blood sugar is known to increase during acute illness due to the inflammatory response that it produces but there is no evidence to suggest whether HbA1c and other measures of blood sugar control are reliable during this time. If HbA1c is unaffected by acute illness then it could be used to differentiate high blood sugar due to the inflammatory response from new onset type 2 diabetes. This would help with the management of acutely ill patients with previously unknown diabetes.
Thirty patients having elective orthopaedic surgery will have blood and urine samples taken pre- and post-operatively in order to analyse whether there is a change in the markers of blood sugar control due to the inflammatory response caused by surgery. Blood samples will be collected with blood tests taken as part of the routine care. Volunteers will need to be over eighteen and not be previously diagnosed with diabetes or any conditions known to affect HbA1c. Patients will be recruited at pre-operative assessment clinics at New Cross Hospital. Orthopaedic surgery has been chosen as the expected blood loss is minimal and patients are generally well. The project will be funded by the clinical chemistry research and development trading account at New Cross Hospital.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
14/SC/1396
Date of REC Opinion
28 Nov 2014
REC opinion
Further Information Favourable Opinion