The effect of plasma proteins on tissue regeneration
Research type
Research Study
Full title
The effect of Plasma Rich in Growth Factors (PRGF) on periodontal tissue regeneration BTI/NW - 03/18
IRAS ID
233231
Contact name
Nicola West
Contact email
Sponsor organisation
Univeristy of Bristol
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Periodontitis is a very common, chronic inflammatory disease with many causes, that presents as progressive destruction of the structures around the tooth, for example bone supporting the teeth. Ultimately, it can lead to tooth loss, poor aesthetics, reduced chewing function and the need for tooth replacement treatment. Routine treatments for periodontal disease are classed as surgical (raising the gum to clean around the tooth) or non-surgical (cleaning around the tooth without raising the gum). If surgical treatment is required, bone rebuilding procedures can also be performed if bone loss around the tooth has occurred.
A new way of aiding the rebuilding and healing of tissue around teeth following surgery is with the use of a blood product derived from the patients own blood called PRGF (plasma rich in growth factors, marketed as PRGF-Endoret). It is known that PRGF enhances tissue healing and also improves the clinical outcomes of various surgical procedures by minimizing post-operative complications such as pain and inflammation/swelling. Venous blood is taken from the patient prior to surgery. The blood is then treated and heated to form a gel like structure which is then inserted around the diseased tooth at the treatment site. The PRGF then acts on the surrounding tissues to aid healing and regeneration.
The aim of this study is to investigate the effect on enhancing wound healing and regeneration of bone in patients with periodontal bone defects following surgical use of PRGF compared to surgical treatment without the placement of PRGF. This is a single centre, single blind (with respect to the assessing clinician), randomised, two treatment regimen, split mouth study in dental patients with vertical interproximal bony defects requiring surgical treatment. At least 60 participants will partake in the study. The University of Bristol are the sponsor and the funder for this study.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
18/SW/0102
Date of REC Opinion
10 Jul 2018
REC opinion
Further Information Favourable Opinion