The effect of oral iron supplementation on phosphate homeostasis
Research type
Research Study
Full title
The acute effects of a single oral iron dose on FGF23 and phosphate metabolism in mildly iron deficient but otherwise healthy women from the UK
IRAS ID
157444
Contact name
Vickie Braithwaite
Contact email
Sponsor organisation
MRC Human Nutrition Research
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Recent studies have suggested a link between phosphate and iron metabolism but this is incompletely characterised. In particular, that iron deficiency causes an increase in FGF23, a hormone produced in bone which regulates phosphate in the body. However, short term effects of oral iron on FGF23 and phosphate metabolism are unknown.
This proposed add-on study will help to assess the acute effects of oral iron supplementation (with ferrous sulphate) on markers of phosphate and bone mineral metabolism.
We seek permission to measure markers of phosphate and bone mineral metabolism in a subset of residual plasma samples (n=42 female participants, aged 18-45 years) from the ferrous sulphate arm of the study entitled “A pilot study to assess the influence of dietary organic acids on iron absorption” (Ref: 06/Q0102/47).
This study will help to provide preliminary evidence of the effects of oral iron supplementation on acute changes in markers of phosphate and bone mineral metabolism.
There will be no further contact with participants.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
15/EE/0191
Date of REC Opinion
27 Apr 2015
REC opinion
Favourable Opinion