The Effect of Mood, Gut-specific Anxiety, and Resilience on IBD VS1.
Research type
Research Study
Full title
An Inception Cohort to Assess the Influence of Anxiety, Depression, Gastrointestinal Symptom-specific Anxiety, and Resilience on the Future Prognosis of Inflammatory Bowel Disease.
IRAS ID
321367
Contact name
Alexander Ford
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
15 years, 0 months, 1 days
Research summary
Inflammatory bowel disease (IBD) includes both Crohn’s disease (CD) and ulcerative colitis (UC). These conditions fluctuate between periods of remission and flare. During flares symptoms of abdominal pain, diarrhoea, and the passage of blood and mucus in stools are common.
Symptoms of mental disorders are more common in IBD than in the general population. Recent research within our group has examined how these symptoms may affect IBD activity during follow-up. We have shown that patients with abnormal mood scores may have worse disease outcomes than people with normal scores. We have also shown that patients with a recent diagnosis of IBD are more likely to develop abnormal mood scores.
Gastrointestinal symptom-specific anxiety is a behavioural response to tummy symptoms. Levels may be higher in patients with IBD. Research suggests this may, in turn, influence patients' social activities, lifestyle choices, and whether they choose to take their treatments. Studies have also shown that resilience levels (the ability to adapt) may affect IBD activity, quality of life, and need for surgery. However, these studies only measure associations at a single point in time. They cannot prove whether these factors truly lead to worse disease outcomes.
We aim to assess the influence of these factors on prognosis of IBD in those with a recent diagnosis. This will help us to know whether there is a role for targeting aspects of mental health and resilience in a particular group of patients with IBD.
REC name
Wales REC 7
REC reference
22/WA/0368
Date of REC Opinion
23 Dec 2022
REC opinion
Further Information Favourable Opinion