The Effect of Local Anaesthetic with Adrenaline on Sinus Surgery
Research type
Research Study
Full title
The Effect of Injected Local Anaesthetic with Adrenaline over Topical Anaesthetic and Decongestion on Sinus Surgery
IRAS ID
295824
Contact name
Miran Pankhania
Contact email
Sponsor organisation
The Rotherham NHS Foundation trust
Duration of Study in the UK
0 years, 10 months, 0 days
Research summary
There is limited evidence regarding the use of injected local anaesthetic over and above topical anaesthetic for endoscopic sinus surgery but there is a contemporary systematic review from 2018 performed in London which looks at 7 RCTs over a 70 year period suggesting that the injection of local anaesthetic with adrenaline improves the surgical field and reduces pain over a 24-hour period post-operatively.
The studies reviewed in this systematic review are very heterogeneous and therefore a good meta-analysis of data does not exist. This review did however mention the use of mean arterial pressure (1/3 systolic BP / 2/3 diastolic BP) and pulse in response to the injection of local anaesthetic and adrenaline but did not go as far as using them as surrogate markers for intra-operative pain, which is what our study aims to undertake.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
21/WM/0193
Date of REC Opinion
13 Aug 2021
REC opinion
Further Information Favourable Opinion