The effect of IPD on lateral bone augmentation
Research type
Research Study
Full title
Influence of Individual Phenotypical Dimension (IPD) on hard tissue stability following lateral bone augmentation: a two-centre clinical study
IRAS ID
358068
Contact name
Nikos Mardas
Contact email
Sponsor organisation
Queen Mary University of London
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
NCT06999915 , NCT number
Duration of Study in the UK
2 years, 4 months, 1 days
Research summary
Guided Bone Regeneration (GBR) is a widely used technique during dental implant surgery to rebuild bone around the implant and improve its long-term appearance and stability. However, a knowledge gap remains as to whether outcomes depend more on an individual’s bone anatomy than on the amount of graft material used. This study investigates the hypothesis that the amount of bone that regrows depends on a person’s original bone shape, known as the Individual Phenotypical Dimension (IPD). The aim is to compare bone stability and other clinical outcomes between two grafting approaches: adding bone only up to the original bone line (IPD) or beyond it (over-contour augmentation). Over one year, the study will assess bone and soft tissue healing, gum blood flow, implant success, and patient satisfaction.
There will be two treatment groups – one will receive bone grafting up to their natural bone shape, while the other will receive a graft extending approximately 3 mm beyond it. 3D radiographs (Cone Beam Computed Tomography – CBCT) will be taken throughout the study to assess changes in bone shape and thickness over time after surgery.
This is a two-centre, prospective clinical trial with two parallel groups, aimed at radiographically comparing the stability of newly formed bone following different GBR protocols (contour vs over-contour augmentation). The study includes approximately 12 visits over 16 to 18 months.
It will take place at the Centre for Oral Clinical Research (COCR), Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London, under The Royal London Dental Hospital, Barts Health NHS Trust, United Kingdom (leading centre), and at the Implant Research Centre and Department of Periodontology & Oral Medicine, School of Dental Medicine, University of Belgrade, Serbia.
The International Team for Implantology (ITI), a global organisation supporting research and education in implant dentistry, is funding this project.
Patients will benefit from receiving high-standard treatment in a well-controlled environment and will not be exposed to additional risks beyond standard care.
REC name
London - Fulham Research Ethics Committee
REC reference
25/LO/0847
Date of REC Opinion
6 Jan 2026
REC opinion
Further Information Favourable Opinion