The effect of DHA- & EPA-enriched oils on cognitive function and mood
Research type
Research Study
Full title
Efficacy Evaluation of 26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Cognitive Function and Mood in Healthy Adults
IRAS ID
203054
Contact name
Philippa Jackson
Contact email
Sponsor organisation
Pronova BioPharma Norge AS, part of BASF
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 11 months, 28 days
Research summary
In humans, supplementation studies that have assessed the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cognitive function in healthy adults have varied widely in their methodology and have yielded inconclusive results. Several methodological factors that have been identified as potentially contributing to these weak conclusions include dose, duration of treatment, sample population and appropriate selection of outcome measures. In addition, very little is known about the effects of EPA supplementation on cognitive outcome despite recent evidence from short term trials indicating treatment with EPA in healthy adults may be relevant to cognitive function in this population. Lastly, there is also some evidence that bioavailability of fatty acids may be greater when taken before sleep. The present study will therefore investigate the effects of EPA- and DHA-enriched oils dosed at bed time, on cognitive function (episodic memory, attention, working memory, executive function), subjective mood, alertness and mental fatigue after 26 weeks daily dietary supplementation.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
16/YH/0224
Date of REC Opinion
22 Aug 2016
REC opinion
Further Information Favourable Opinion