The Effect of Bariatric Surgery on Plasma Annexin A1 levels; VN: 1
Research type
Research Study
Full title
Plasma Annexin A1 levels and insulin sensitivity during weight loss through Bariatric Surgery.
IRAS ID
220666
Contact name
Derek Renshaw
Contact email
Sponsor organisation
Coventry University
Duration of Study in the UK
0 years, 8 months, 31 days
Research summary
Recently, the adipose tissue has been acknowledged to be more than just a site of lipid storage as it contribute to metabolic homeostasis through the secretion of adipose tissue specific proteins; the “adipokines”. Obesity refers to excess lipid storage in the adipose tissue often leading to ectopic deposition in other organs affecting their physiological function. Bariatric surgery; otherwise known as weight loss surgery is thought to be an effective option for individuals who are morbidly obese or have a BMI of over 40. However, individuals often exhibit alterations in the levels of adipokines and insulin sensitivity leading to insulin resistance, despite weight loss. Therefore, the aim of this project is to investigate the plasma levels of an anti-inflammatory protein Annexin A1 (AnxA1) during weight loss through bariatric surgery. AnxA1, like other anti-inflammatory proteins is thought to influence insulin activity and preliminary data suggest it decreases the levels of pro-inflammatory markers which may contribute to effective resolution of inflammation and development of diabetes type 2 in these patients. Furthermore, other inflammatory biomarkers will be assessed and correlated with AnxA1 and insulin sensitivity.
Upto 30 patients undergoing bariatric surgery will be recruited for a period of 3 months. These patients will include diabetic and non diabetic obese individuals who are due to undergo planned surgery. Glucose Tolerance Test (OGTT) and Blood samples will be collected at 3 different time points including; pre-operation, 6 weeks and 3 months post operation. The samples will be analysed for inflammatory biomarkers, insulin sensitivity and gut hormones.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
17/NE/0254
Date of REC Opinion
17 Aug 2017
REC opinion
Further Information Favourable Opinion