The East London Parkinson’s Disease Project
Research type
Research Study
Full title
The East London Parkinson’s Disease Project
IRAS ID
242395
Contact name
Alastair Noyce
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. The relationship between clinical phenotype and genotype in patients with PD has been almost exclusively studied in Caucasian populations. This project seeks to contribute to collaborative efforts studying the relationship between clinical phenotype and genotype in PD, but also to provide a substantial contribution to exploring these relationships in non-Caucasian patients, given the high proportion of ethnic minority groups in East London. Additionally, there is an ongoing need for objective biomarkers of PD to both aid in diagnosis, pre-diagnosis (prodromal PD), monitor disease progression, and to help understand the underlying pathogenesis. We believe that using high-throughput lipidomic and proteomic analyses can identify subtle changes in respective lipid or protein/RNA expression in PD patients relative to healthy controls. This project will consider two independent biomarkers, and collect both from the same patient cohort and control cohort.
REC name
South West - Central Bristol Research Ethics Committee
REC reference
18/SW/0255
Date of REC Opinion
29 Nov 2018
REC opinion
Further Information Favourable Opinion