The difference in releasing of EMPs in T2DM
Research type
Research Study
Full title
Impact of glycaemic control on levels of microparticles and clotting in patients with Type 2 Diabetes Mellitus.
IRAS ID
179405
Contact name
Thozhukat Sathyapalan
Contact email
Sponsor organisation
Hull and East Yorkshire Hospitals NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
It has been known that the high glucose concentration in the blood as in diabetes patients can effect many organs on the long term. One of that organs is the inner cell layer of blood vesicles which is called endothelial cells. Damaging of the endothelial cells may lead to several complications such as heart problems. However, there is no screening test that can recognize this damage in early stage which will be very helpful for prevention and early treatment. Therefore, in this study we are trying to find a useful laboratory method to identify the cell damage by measuring ‘cellular factors’ which is called as endothelial microparticles. These factors are also essential in the clotting process inside the body, and the increasing amount of micropartcles may also lead to clotting complications. As we know Type 2 Diabetes patients are at high risk of developing endothelial dysfunction and subsequently heart problems. So we are studying two groups of type 2 diabetes patients, one in whom the diabetes is suboptimal controlled and the second group in whom diabetes is adequately controlled
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
16/YH/0183
Date of REC Opinion
16 Aug 2016
REC opinion
Further Information Favourable Opinion