The detection of EGFR mutations in liquid based cytology samples

• Research type

  Research Study

• Full title

  Use of the Idylla platform for the detection of EGFR mutations in liquid- based cytology specimens of lung adenocarcinoma

• IRAS ID

  261622

• Contact name

  James Garvican

• Contact email

  j.garvican@nhs.net

• Sponsor organisation

  Royal Cornwall Hospital Trust

• Duration of Study in the UK

  0 years, 10 months, 3 days

• Research summary

  This study will investigate whether liquid based cytology specimens are a feasible alternative to formalin-fixed paraffin embedded histology samples for detection of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma using the Biocartis Idylla platform. The Biocartis Idylla is a fully automated, real-time PCR based molecular diagnostics system. The Idylla carries out the entire analytical process from sample to result.
  This study will be based in the cytology department at Royal Cornwall Hospital as part of a service improvement. It will use residual material from existing samples sent to the laboratory as part of the routine service. It will use existing material from patients diagnosed with lung adenocarcinoma by cytology using the current, validated procedure which uses formalin-fixed paraffin embedded (FFPE) samples over a 10 month period. EGFR mutation results obtained using the validated procedure (formalin fixed paraffin embedded) will be compared to those produced using liquid based cytology samples.

• REC name

  London - Riverside Research Ethics Committee

• REC reference

  19/LO/0808

• Date of REC Opinion

  7 May 2019

• REC opinion

  Favourable Opinion