The Control of Innate Immunity in disease
Research type
Research Study
Full title
The Control of Innate Immunity, Host-Pathogen Interactions, and Leukocyte Function in Disease
IRAS ID
254367
Contact name
Ian Sabroe
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Summary of Research
The immune system is essential for fighting infection, fighting cancer, and healing wounds. The immune system can also go wrong, and when it becomes active at the wrong time it can cause inflammatory diseases like asthma or arthritis. If the immune system is not active enough or not properly coordinated, infections can get a foothold or wounds don't heal.
The immune system is very carefully controlled. The academic unit of respiratory medicine has spent over 20 years studying how the immune system works. Most of these studies are done with blood cells taken from healthy volunteers. We want to take the lessons we've learnt from healthy people and see how they apply to people with illness.
This application is to allow us to consent people with a range of illnesses that we are interested in, with a plan to take blood from them to study in the laboratory. We want to see if the immune system behaves differently in people with an illness, and to see whether discoveries we make can be developed into new ways of treating illness.Summary of Results
This study terminated early with no results.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
18/EE/0369
Date of REC Opinion
6 Dec 2018
REC opinion
Further Information Favourable Opinion