The challenges in Diagnosing 1o & 2o lung SCC – a new approach v1.0
Research type
Research Study
Full title
The challenges in diagnosis of primary and secondary lung squamous cell carcinoma – A new approach.
IRAS ID
173537
Contact name
Christopher Gratze
Contact email
Sponsor organisation
Basildon and Thurrock University NHS Foundation Trust
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
0 years, 6 months, 5 days
Research summary
Determining whether squamous cell carcinoma (SCC; a type of lung cancer) of the lung originates in the lung (primary) or has spread from another region of the body (secondary) continues to be a challenge as currently there is no reliable means of testing between these disease states. Determination of this would be beneficial as lung cancer remains to be a leading cause of cancer mortality, and treatment regimes vary between primary and secondary disease. If the SCC type is known then personalised therapy and potentially better patient prognosis may be realised.
This study proposes to use four markers to attempt to discern between such primary lung SCC and SCC which has spread from other regions of the body by identifying marker associated with cell types such other regions. Of these, a marker for High risk Human Papilloma Virus (HPV) will be used due to well known associations with SCC of the cervix, and to investigate a suggested link between HPV and SCC from other areas of the body.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
15/NW/0402
Date of REC Opinion
6 May 2015
REC opinion
Favourable Opinion