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The CFI Study

  • Research type

    Research Study

  • Full title

    The Complement Factor I in Age-related Macular Degeneration Study (the CFI study)



  • Contact name

    Andrew Lotery

  • Contact email

  • Sponsor organisation

    University Hospital Southampton Foundation Trust

  • Duration of Study in the UK

    1 years, 11 months, 30 days

  • Research summary

    Mutations in the gene for the complement factor I (CFI) protein has been found in patients with AMD. Furthermore low CFI protein levels have been found in the blood of patients with AMD and CFI gene mutations. This project aims to identify patients with advanced dry AMD (geographic atrophy), low blood CFI levels together with CFI mutations. These patients may then be offered potential future studies targeting CFI supplementation.

  • REC name

    Yorkshire & The Humber - South Yorkshire Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    13 Jun 2017

  • REC opinion

    Favourable Opinion