The CARMA Study
Research type
Research Study
Full title
Child and Adolescent Reservoir Measurements on early suppressive ART (CARMA Study)
IRAS ID
227799
Contact name
Caroline Foster
Contact email
Sponsor organisation
PENTA Foundation
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Antiretroviral therapy (ART) can suppress but not cure HIV as even with effective treatment around 1 in a million white cells remain infected with HIV - called the latent reservoir. Children born with HIV who started ART early, within the first months of life and have remained on ART since that time, may have smaller reservoir. These children maybe ideal candidates for future interventions aiming at inducing ART free remission. We would like to take some extra blood samples at the time of routine clinical care to look in detail at the immunology and virology of 40 children/adolescents across Europe who started ART early and have always had a suppressed HIV viral load. We hope that this study will enable us to identify characteristics the of children with a low reservoir for future interventional studies.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
17/LO/1182
Date of REC Opinion
14 Sep 2017
REC opinion
Further Information Favourable Opinion