The Bronchiectasis and Community Acquired Pneumonia (B-CAP) study.
Research type
Research Study
Full title
Evaluation of adults admitted to hospital with community acquired pneumonia and non-cystic fibrosis bronchiectasis: a multicentre, retrospective observational cohort study.
IRAS ID
256786
Contact name
Alice Turner
Contact email
Sponsor organisation
University Hospitals Birmingham NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Bronchiectasis is a common and progressive respiratory condition characterised by permanent airway dilatation and chronic inflammation. In the UK, pneumonia accounts for more hospital admissions/bed days than any other lung disease and is the 3rd most common cause of death from lung disease.
In patients admitted to hospital with community acquired pneumonia (CAP) and non-cystic fibrosis (non-CF) bronchiectasis, this study aims to: evaluate the utility of clinical risk prediction scores such as CURB-65 and BAP-65, identify biomarkers that predict clinical outcome and evaluate the association between morphology of underlying lung disease and clinical outcome.
This multicentre, retrospective observational cohort study will include all adult patients (≥18 years of age) admitted with CAP and non-CF bronchiectasis to one of three hospital sites (single NHS Foundation Trust) between 2010 to 2017. Routinely collected clinical data will be extracted from electronic patient records. No additional interventions/procedures will be performed.
This study will help to inform clinicians regarding the accuracy of widely used clinical risk prediction scores and may identify additional biomarkers which can guide clinicians in the treatment of patients admitted to hospital with CAP and non-CF bronchiectasis.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
19/EM/0143
Date of REC Opinion
9 May 2019
REC opinion
Favourable Opinion