The BOLT Study: Behaviours and outcomes after liver transplant v1
Research type
Research Study
Full title
Diet and physical activity behaviours, their determinants, and relationship with quality of life and cardiovascular disease risk factors after liver transplant: a cohort and qualitative study.
IRAS ID
264318
Contact name
Simon Griffin
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
2 years, 9 months, 31 days
Research summary
It is common for people to develop cardiovascular disease, obesity, diabetes, raised cholesterol and high blood pressure after a liver transplant. This increases the risk of poor health and lowers quality of life. A healthy diet and physical activity are important to enable people to stay healthy after transplant. We don’t know whether people have a healthy diet and are physically active after a transplant or not, or what influences these behaviours. This may be different to the general public due to the effects of liver disease, the transplant operation and medication.
This research aims to find out, for liver transplant recipients:
1. What are their diet and physical activity behaviours?
2. What are the factors influencing these behaviours?
3. Are diet and physical activity behaviours associated with cardiovascular disease risk factors and quality of life?Knowing the answers to these questions will help to improve post-transplant care.
What will this research involve?
Part 1:
We will invite patients who have a liver transplant at Cambridge University Hospitals NHS Foundation Trust to participate when they are 4-5 months post-transplant. At 6 and 12 months after transplant we will measure quality of life, diet, physical activity and things that might influence diet and activity. We will collect information on risk factors for cardiovascular disease, such as blood pressure and cholesterol levels. With this information we will look at the links between diet, activity, cardiovascular disease risk factors, quality of life and the reasons for diet and activity behaviours.Part 2:
We will invite some participants from part 1 of the study to interviews to explore the things influencing their diet and activity in more depth. We will choose people who have a range of diet and activity behaviours, so that a range of experiences are explored.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
19/WM/0322
Date of REC Opinion
25 Oct 2019
REC opinion
Favourable Opinion