The blinking dynamics and the ocular surface lubrication in ptosis & d
Research type
Research Study
Full title
The application of high speed camera to study the blinking kinesis before and after blepharoplasty and blepharoptosis correction compared with the status of the ocular surface lubrication.
IRAS ID
185636
Contact name
Daniel Ezra
Contact email
Sponsor organisation
Moorfields Eye Hospital
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
This study looks into the dynamics of the eyelid motion during the blinking process in 2 different upper lid conditions: dermatochalasis and blepharoptosis. We compare the pre and post operative of the blinking dynamics recorded by a high speed camera, using a control group as normal blinking baseline.
It also compares the status of the ocular surface lubrication with the blinking pattern pre and post operatively.
The study uses a high speed camera recording 500 frames per second. The imaging of one spontaneous and one voluntary blink is analysed. The frequency and the duration of a complete blinking are recorded. For each blinking every frame (2ms apart) is analysed and the palpebral aperture is manually measured. The measurements of the palpebral aperture are then put in chronological order in a graphic and the resulted curve represents the pattern of a complete blinking (from the time the closure starts until the total return of the upper on its original position before the blinking motion starts). For each group studied the pattern of the curve of a blinking dynamic showed in the graphic is compared with the status of the lubrication of the ocular surface. It aims to identify any correlation between these two data. This study also compares the pattern of the curve of a blinking dynamic showed in the graphic pre and post operatively following surgeries of blepharoplasty and blepharoptosis correction.
It is a joint study with the Mechanical Engineering Department of University College London (UCL) from where the high speed camera will be brought to Moorfields Eye Hospital (MEH) for few weeks in both phases of the study, pre and post operatively.
It is a safe and simple observational case control study that does not involve any intervention.REC name
East of Scotland Research Ethics Service REC 1
REC reference
15/ES/0171
Date of REC Opinion
15 Oct 2015
REC opinion
Further Information Favourable Opinion