The arrhythmogenic potential of midwall septal fibrosis in DCM
Research type
Research Study
Full title
The arrhythmogenic potential of midwall septal fibrosis in non-ischaemic dilated cardiomyopathy – A combined ECGI and CMR investigative study
IRAS ID
290788
Contact name
Gabriella Captur
Contact email
Sponsor organisation
University College London JRO
Clinicaltrials.gov Identifier
Z6364106/2021/08/28, UCL Data Protection number
Duration of Study in the UK
2 years, 11 months, 18 days
Research summary
Dilated cardiomyopathy is a common heart condition where your heart weakens, enlarges and stops pumping efficiently. It can make you feel breathless but worryingly some people experience dangerous heart rhythms. Therefore, some are advised to have a special ‘defibrillator’ put in, which can deliver a shock to stop dangerous heart rhythms. As defibrillators can have many unwanted effects, doctors do not fit them into every patient, but instead try to choose those patients who they think are at greatest risk. The problem is that doctors are not very good at choosing the high-risk patients: many patients with weak hearts who do not have a defibrillator experience dangerous heart rhythms and die, and many patients who have a defibrillator never seem to need it!
In this study, we are trying to better predict who is actually at higher risk of dangerous heart rhythms. We will take MRI pictures of the heart and look at the electrical rhythm with a special vest. From this, we generate computer models of your heart to predict if you are at high risk of dangerous heart rhythms. We hope this will improve how we identify the high-risk patients who need defibrillators, in order to save more lives.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
21/NW/0333
Date of REC Opinion
24 Nov 2021
REC opinion
Further Information Favourable Opinion