The analysis of the faecal microbiome in inflammatory bowel disease
Research type
Research Study
Full title
A Study of the Faecal Microbiome in Inflammatory Bowel Disease Patients with and without Irritable Bowel Syndrome-type Symptoms. GA14/11071
IRAS ID
149548
Contact name
Peter John Hamlin
Contact email
Sponsor organisation
Leeds Teaching Hospitals
Research summary
People with inflammatory bowel disease often report symptoms related to their intestines, even when their disease is relatively well-controlled (known as being in remission). These symptoms are sometimes thought to be in keeping with another chronic disorder of the intestines, irritable bowel syndrome. Irritable bowel syndrome is a much more common condition than inflammatory bowel disease, so sometimes it is difficult for doctors to know whether people with inflammatory bowel disease who report these types of symptoms do so because of ongoing inflammation in the intestine, or because they also suffer from irritable bowel syndrome. Some scientists have shown that the bugs that live in the intestine are quite different in patients with either inflammatory bowel disease or irritable bowel syndrome, compared with healthy people.
The aim of this project is to increase our understanding of the relationship between the bugs that live in the intestine, and symptoms that are in keeping with irritable bowel syndrome in people with inflammatory bowel disease. We will analyse stool samples that we collected as part of a previous study, in order to see whether there are any obvious differences in the population of bugs in the intestine between inflammatory bowel disease patients who do, and who do not, report symptoms that sound like irritable bowel syndrome.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
14/NW/0143
Date of REC Opinion
14 Mar 2014
REC opinion
Favourable Opinion