The analysis of RNA from human tissue
Research type
Research Study
Full title
A comprehensive analysis of RNA from healthy and diseased human tissue samples.
IRAS ID
278608
Contact name
Dan Leggate
Contact email
Sponsor organisation
Storm Therapeutics Ltd
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
9 years, 11 months, 28 days
Research summary
Ribonucleic Acid (RNA) has been understood for many years to be the conduit through which the protein-coding genes in DNA are converted into proteins. An RNA version of a gene (mRNA) is made by RNA polymerase acting upon the DNA template and this is then used to assemble the protein using transfer and ribosomal RNA (tRNA and rRNA respectively). The control of this process was always believed to be the rate of production and degradation of these RNA molecules but in recent years it has become apparent that there is an extra level of complexity. The RNA molecules are themselves chemically modified after they have been made and these modifications play a significant role in their function. The study would like to explore the nature of these modifications in both healthy and diseased human tissues, identify modification sequence locations and correlate these data with expression analysis.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
21/WM/0043
Date of REC Opinion
15 Feb 2021
REC opinion
Favourable Opinion