The ACUTE Study
Research type
Research Study
Full title
The ACUTE Study - A mechanistic study of intravenous thiamine in heart failure
IRAS ID
266455
Contact name
Matthew Reed
Contact email
Sponsor organisation
ACCORD
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Summary of Research:
This study is being carried out to determine whether giving thiamine, an essential vitamin, through a drip in the arm, alters the blood level of a protein, brain natriuretic peptide (BNP). It is common for people with a diagnosis of heart failure to lack thiamine in their body, due to a number of factors including eating less, other health problems and medications, especially diuretics which are commonly referred to as 'water tablets'. Not having enough thiamine has the potential to cause weight loss, confusion, muscle weakness and make the heart work less well. Patients who are aged 18 and over, diagnosed with heart failure, taking diuretic medicines, being admitted to hospital and able to give informed consent will be eligible to join the study. Patients will be identified in the Emergency Department or wards of the Royal Infirmary of Edinburgh. Participants will be allocated at random (like tossing a coin) into one of two groups. One group will continue to be treated as normal and have three blood samples taken during their admission. The other group will be given a vitamin preparation called Pabrinex (which contains thiamine) during their hospital admission and also give three blood samples. Pabrinex is routinely used in hospitalised patients. We will measure the blood concentrations of BNP and another protein, troponin, in these patients to identify the effect of thiamine.Summary of Results:
Intravenous thiamine resulted in a reduction in NTproBNP, but not hsTnI, concentrations in patients with acute heart failure previously receiving a loop diuretic.REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
20/YH/0322
Date of REC Opinion
26 Nov 2020
REC opinion
Favourable Opinion