The acute effects of Food Structure on Appetite Regulation

• Research type

  Research Study

• Full title

  The Acute Effects of Food Structure on Appetite Regulation

• IRAS ID

  133586

• Contact name

  Gary Frost

• Contact email

  g.frost@imperial.ac.uk

• Sponsor organisation

  Imperial College London and Imperial College Healthcare NHS Trust

• Duration of Study in the UK

  0 years, 5 months, 1 days

• Research summary

  AIMS: To investigate the effects of different food structures on appetite signals from the upper gastrointestinal tract.

  DESIGN: Crossover, controlled, clinical trial.

  POPULATION: Healthy adults (no diagnosed diseases) aged between 18 and 65 years.

  INTERVENTION: Solid meal group.
  Milled (destroyed-cell) meal group.
  Milled (intact-cell) group
  All of which contain the same foods (chickpeas, sesame oil, and apple)

  DURATION: five weeks (1 screening visit + 4 study visits, one week apart)

  OUTCOME MEASURES:
  • Difference in gastric emptying rate
  • Difference in appetite regulatory hormones (CCK, PYY, GLP-1 and ghrelin) levels and release time
  • Difference in energy intake at a given ad-libitum meal
  • Difference in appetite regulation as measured by VAS

• REC name

  London - Stanmore Research Ethics Committee

• REC reference

  16/LO/0209

• Date of REC Opinion

  1 Apr 2016

• REC opinion

  Further Information Favourable Opinion