Testing and evaluation of modified decellularisation processes
Research type
Research Study
Full title
Testing and evaluation of modified decellularisation processes on bone-tendon-bone, bone-tendon and tendon structures.
IRAS ID
288512
Contact name
Jennifer H Edwards
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 7 months, 31 days
Research summary
Decellularisation is a process that removes cellular material from a biological tissue, making it suitable as a tissue graft with a lower risk of rejection by the patient. The decellularisation process has been adapted previously to work with human dermis and bone-tendon-bone tissues, with the dermis now supplied by NHS Blood and Transplant (NHSBT) for use in the UK. The process is tissue specific and must be modified for each new tissue to balance cell removal and tissue properties.
In order to maximise the benefits of this process, it must be streamlined for use by NHSBT. This study will investigate modifications to the decellularisation process on bone-tendon-bone, bone-tendon and tendon only grafts for anterior cruciate ligament repair to reduce the length of time required to process the tissues. Following development, characterisation work will be carried out to confirm that the changes to the process do not result in loss of mechanical properties compared to the standard decellularisation process and native tissue.
REC name
HSC REC A
REC reference
21/NI/0173
Date of REC Opinion
19 Oct 2021
REC opinion
Favourable Opinion