Test And Detect Antibodies in HPV Vaccinated Women Study
Research type
Research Study
Full title
Test And Detect Antibodies in HPV Vaccinated Women Study (TADAH Study)
IRAS ID
127482
Contact name
Karly Louie
Contact email
Sponsor organisation
Queen Mary University of London
Research summary
Evidence shows that vaccination has not been well recorded for up to 25% of eligible girls in the NHS (Louie KL, unpublished data 2013) and there is also evidence that at least 10% of girls do not know their HPV vaccination status (Bowyer HL et al, Vaccine 2013). The research aims to identify an easy and acceptable test that could be used to confirm a woman’s HPV vaccination status. A woman’s known HPV vaccination status will be needed to measure the long-term impact of the vaccine and inform on different cervical screening strategies in the future (e.g. different intervals of screening for full vaccinated vs. unvaccinated). The study aim is to identify an easy, non-invasive and acceptable method for confirming HPV vaccination status.
In addition, we want to obtain exploratory data on whether the HPV vaccine also has the potential to protect against infection in the mouth and hands as compared to the cervix. We know from clinical trials that the HPV vaccine is more than 95% effective in preventing infection in the cervix among girls naive to HPV-16/18. However, we do not know if the vaccine is also working in preventing infection in the mouth and hands. The incidence of oropharyngeal cancers (OPCs) in England has been increasing in the last 15-years and is continuing to increase (Louie KS et al¸ IPV Conference & Abstracts 2012). And there is a sub-set of OPCs that are HPV-related and nearly 90% of HPV-positive related OPCs are infected with HPV-16. If the HPV vaccine does work in preventing infection in the mouth and hands, then it has the potential to prevent the majority of HPV-related OPCs in the future. Data from this study will provide preliminary evidence as to whether vaccine can offer additional protection of infection in the mouth and hands.
REC name
London - Harrow Research Ethics Committee
REC reference
13/LO/1729
Date of REC Opinion
18 Dec 2013
REC opinion
Favourable Opinion