Test And Detect Antibodies in HPV unvaccinated women Study-2
Research type
Research Study
Full title
Test And Detect Antibodies in HPV unvaccinated women (TADAH-2) Study
IRAS ID
180218
Contact name
Karly Louie
Contact email
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
The purpose of the study is to find out the best test for confirming whether or not a woman has been vaccinated with the HPV vaccine (the cervical cancer vaccine). Women are being asked to participate because they have NOT been vaccinated with the HPV vaccine.
HPV vaccination aims to prevent women from developing cervical cancer. In 2008, a national HPV immunisation programme was introduced in the UK to routinely vaccinate girls aged 12-13 yrs old. A test to confirm vaccination status is needed so that in the future, we will be able to measure how many cases of cervical cancer have been prevented
When a woman comes into contact with HPV her body responds by producing antibodies to the virus. The presence of HPV antibodies indicates that a woman has been exposed to the virus at sometime in her life and the body is working naturally to defend itself. The same process happens when a woman is vaccinated against HPV but the levels of antibody are much higher.
We want to identify a simple, non-invasive test to determine a woman’s HPV vaccination status, as it will be important to compare cancer rates in women who have not been vaccinated with those who have. Not everyone will be able to remember whether they were vaccinated as a teenager.
We already know what antibody levels to expect in blood samples taken from women who have or have not been vaccinated but we do not know how the antibody levels in finger prick and saliva samples of vaccinated women compare with the levels in unvaccinated women. We are therefore collecting blood, finger prick and saliva samples from women to see how well these different tests can differentiate between women who are vaccinated or unvaccinated with the HPV vaccine.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
15/LO/1093
Date of REC Opinion
7 Jul 2015
REC opinion
Favourable Opinion