TEG in MT
Research type
Research Study
Full title
Use of thromboelastography to predict massive transfusion in trauma patients
IRAS ID
247491
Contact name
Adam Brooks
Contact email
Sponsor organisation
Nottingham University Hospitals, Research and Innovation
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Bleeding is the second leading cause of death after injury (following central nervous system injury), and is the leading cause of preventable trauma deaths accounting for 30-40% of fatalities.
Patients suffering from trauma and significant bleeding can rapidly develop abnormalities in the clotting system which can lead to further blood loss and worsened outcomes.
These patients may hence require massive transfusion to counteract this. Massive transfusion is described as needing ten or more units of blood cells within the first 24 hours of injury and can be a lifesaving therapy.
It is important to rapidly identify those patients who are in need of massive transfusion and may have altered clotting. Thromboelastography (TEG) is a bedside test that can be used to promptly measure the clotting profile of whole blood. Previous research into TEG has shown that certain measurements derived from the test can be used as a predictive tool to identify patients needing massive transfusions.
This study will look into the TEG results of trauma patients and try and identify any predictive measures from test to predict the requirement of massive transfusion.REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
18/YH/0298
Date of REC Opinion
18 Jul 2018
REC opinion
Favourable Opinion