TEG 6S in term parturients

• Research type

  Research Study

• Full title

  An observational study of normal values of coagulation in term pregnant women undergoing elective caesarean section using TEG6 (haemonetics)

• IRAS ID

  243531

• Contact name

  Lizzie Maronge

• Contact email

  lizzie.maronge@nuh.nhs.uk

• Sponsor organisation

  Nottingham University Hospitals' Trust

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Summary of Research

  TEG6 is a bedside clotting test which gives rapid results. Currently there is no data on the clotting values in pregnant women using this piece of equipment. This study would involve taking a sample of blood from term women having an elective section at the time of cannula insertion (a procedure which is required for surgery). This sample would then be anonymised and analysed and a normal range generated. This data could then be used to aid the management of massive haemorrhage in pregnant women.

  Summary of Results

  120 pregnant women were recruited with a mean age of 32.68 years, mean weeks gestation 39.29, mean parity of 1. Independent sample t-test was used to calculate p values; we assumed non-pregnant ranges contained 95% of the population.
  We specifically looked at CK-R time - (the time taken to start clotting) and CFF-MA (clot strength). These results were both statistically different to the non pregnant population. Both had p<0.0001

  Our results have demonstrated differences in TEG6s values in the healthy term obstetric population compared to those used in the non-pregnant population. It is reasonable to produce separate guidelines with differing thresholds for intervention in MOH. Using these results, we have produced a treatment algorithm for the use of the TEG6s in MOH, which is about to be implemented in our trust.

• REC name

  London - Surrey Borders Research Ethics Committee

• REC reference

  20/LO/0750

• Date of REC Opinion

  28 May 2020

• REC opinion

  Favourable Opinion