TCPO2 Improvements following revascularisation intervention
Research type
Research Study
Full title
Does Transcutaneous Pressure of Oxygen (TcpO2) improve following intervention (bypass or stent) in patients with occlusive peripheral arterial disease?
IRAS ID
252558
Contact name
Harriet Robinson
Contact email
Sponsor organisation
Newcastle University
Duration of Study in the UK
0 years, 4 months, 12 days
Research summary
Peripheral arterial disease (PAD) is the narrowing of arteries (most commonly in the legs) due to the build up of plaque. This can lead to a reduced blood supply to the feet and the development of non-healing wounds and rest pain. These patients are often offered surgical intervention, to improve blood supply, by two methods:
- Bypass graft surgery: a portion of the patient’s own vein or a prosthetic graft is used to bypass the diseased portion of the artery, providing a “diversion” of blood flow around the narrowing or blockage.
- Angioplasty & stenting: a small wire with a balloon on the end is inserted into the diseased artery and inflated to stretch out the narrowing. In some cases a stent is placed into the artery permanently after stretching to hold it open.Transcutaneous Pressure of Oxygen (TcpO2) is a measure of how well oxygen from the blood is delivered to the tissue, and can be used to quantify how bad a patient’s PAD is and used as an indicator for wound healing.
In patients with occlusive PAD you would expect a reduced TcpO2 measurement due to the reduced blood supply. We will be looking at whether there is a post-operative improvement in this measurement, and whether there is a comparison in improvements between diabetic and non-diabetic patients. It may then be possible to use TcpO2 as a measure of success of revascularisation, using the measurements alongside ultrasound scanning to evaluate patient outcomes.REC name
South Central - Oxford B Research Ethics Committee
REC reference
19/SC/0167
Date of REC Opinion
8 Apr 2019
REC opinion
Further Information Favourable Opinion