Tau in relation to TDP-43 CC75C
Research type
Research Study
Full title
Microtubule associated protein tau pathology in relation to the TAR DNA binding protein of 43kDa; associations with dementia in the Cambridge City over-75s Cohort.
IRAS ID
315851
Contact name
Carol Brayne
Contact email
Sponsor organisation
University of Cambridge
Clinicaltrials.gov Identifier
4288, UK Clinical Research Network (UKCRN) CC75C
Duration of Study in the UK
1 years, 7 months, 27 days
Research summary
Abnormal deposits of the proteins called tau and TDP-43 in the brains of older people are two factors associated with dementia and ageing. Recent laboratory investigations have found close associations between these two proteins but studies in human brains found no associations between them or unclear results. We aim to make detailed measurements of tau deposits in brain donations from the Cambridge City over-75s cohort. We will then compare these with the detailed measures of TDP-43 we already have from these same brain donors’ brains. We want to see whether or not these two proteins are strongly associated with each other and, if we find they are, whether this relates to who developed dementia.
REC name
Wales REC 4
REC reference
23/WA/0033
Date of REC Opinion
16 Jan 2023
REC opinion
Favourable Opinion