TARGIT R (registry)
Research type
Research Study
Full title
TARGIT R: Initiation and maintenance of a registry database of patients treated with targeted intraoperative radiation therapy using Intrabeam (TARGIT) following breast conserving surgery for early breast cancer.
IRAS ID
132666
Contact name
Mohammed Keshtgar
Contact email
ISRCTN Number
ISRCTN91179875
Clinicaltrials.gov Identifier
Z6364106/2013/06/13, UCL Data Protection Number
Research summary
Breast cancer is the most common cancer in the UK. Most patients are currently subjected to standard radiotherapy which is given several months after surgery and would normally consist of a 3-5 week course of daily radiotherapy to the whole breast, as well as a shorter 5-8 day course to the tumour bed (the normal breast tissue immediately around the tumour). A recent publication in The Lancet reported the results of the TARGIT A randomised controlled trial in low-risk women over the age of 45 and showed that giving a single dose of radiation with the TARGIT technique at the time of operation gave similar results to the usual several weeks' course of radiotherapy.
Although the clinical trial is closed to recruitment, follow-up continues as this technology is still regarded investigational and has not yet been reviewed and approved by NICE. However, many clinicians feel that there are groups of patients that are suitable candidates for this treatment. Blindness, previous external beam radiotherapy, claustrophobia, or age preclude these patients from having external beam radiotherapy. It is important that patients treated with this technique are monitored for safety and effectiveness.
We therefore wish to set up the TARGIT R (registry) study to gather further information on the technique in a much more diverse population with early breast cancer.
A well-established clinical trials centre will administer this study. The participating centres are self-financing and the equipment is already in place.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
14/LO/1452
Date of REC Opinion
8 Sep 2014
REC opinion
Further Information Favourable Opinion