Tako Genetics Study

• Research type

  Research Study

• Full title

  Is There a Genetic Predisposition for Acute Stress-Induced (Takotsubo)Cardiomyopathy?

• IRAS ID

  245070

• Contact name

  Dana Dawson

• Contact email

  dana.dawson@abdn.ac.uk

• Sponsor organisation

  NHS Grampian

• Duration of Study in the UK

  5 years, 6 months, 31 days

• Research summary

  Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. Using our Scottish-wide, recently established takotsubo cardiomyopathy registry, we propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. We will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

• REC name

  East of Scotland Research Ethics Service REC 1

• REC reference

  18/ES/0053

• Date of REC Opinion

  25 Apr 2018

• REC opinion

  Further Information Favourable Opinion