TACTIC CRT
Research type
Research Study
Full title
A prospective randomised multi-centre Trial comparing cArdiac MRI guided CRT versus Conventional CRT implantation in patients with Ischaemic Cardiomyopathy - TACTIC CRT
IRAS ID
250715
Contact name
C Aldo Rinaldi
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Heart failure patients may benefit from having a special pacemaker implanted to make the heart pump in a more co-ordinated way - Cardiac Resynchronisation Therapy (CRT). For the heart to pump well it is necessary to place the pacing wires in good positions within the heart. Only two thirds of people respond to CRT and this may be because of non-ideal pacing wire position in those that do not respond. This study aims to see whether new advanced imaging technologies and computer software can be used to help guide lead placement and thus allow more people to respond to therapy.
Pilot study work has shown that the advanced technologies proposed can be used in the way we wish to use them. This (main) study will be a randomised controlled trial whereby patients will be randomised to either standard treatment or to an advanced technology group. The patients in the advanced technology arm of the study will undergo special imaging (cardiac MR and 2D echo) prior to implantation of their pacemaker. The images obtained will be superimposed on to the standard X-ray images usually taken during the procedure using special computer software that has been newly developed. The idea is that the patient’s anatomical data (coronary veins, scar) and physiological dyssynchrony (assessment of the co-ordination of heart muscle contraction) information derived from these imaging techniques will help the operator implant the lead and also choose the best site for it.
If the patients in the advanced technology arm do fare better than the patients receiving standard treatment, this may alter how we treat a large population of heart failure patients around the world.
The study requires 218 patients in total and will take 2 years to complete.REC name
London - Stanmore Research Ethics Committee
REC reference
19/LO/0461
Date of REC Opinion
11 Jun 2019
REC opinion
Further Information Favourable Opinion