Systems Medicine Analysis of Inflammatory Bowel Disease
Research type
Research Study
Full title
Systems Medicine Analysis of Inflammatory Bowel Disease
IRAS ID
166728
Contact name
Chris Probert
Contact email
Duration of Study in the UK
2 years, 9 months, 0 days
Research summary
Inflammatory bowel disease (IBD) is a complex condition which is thought to arise due to a combination of factors such as genes, bacteria in the gut and environmental factors such as smoking. The severity and nature of IBD varies from person and person. Some people may require surgery or experience frequent flares while others have a milder disease course. Likewise, people respond differently to various treatments used in IBD. The purpose of the study is to increase our understanding of several aspects of IBD. we plan to look at the role of intestinal and white blood cell signalling in causing IBD. We aim to identify biological markers that help to predict flares, investigate factors that may influence the course of IBD over time and to understand factors that predict response to treatment.
In this study, we will look at genes and protein related to NfkB signaling that controls inflammation. This pathway controls inflammation that underlies IBD. We will study this pathway by analysing genes and proteins from blood samples and biopsy samples from the bowel of patients with IBD and controls.
Understanding this pathway may lead to new treatments for IBD.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
15/NW/0045
Date of REC Opinion
11 Feb 2015
REC opinion
Further Information Favourable Opinion