Systematic review of macular hole outcomes and duration

• Research type

  Research Study

• Full title

  Effect of symptom duration and other variables on functional and anatomical outcomes after surgery for idiopathic full thickness macular hole (iFTMH); a study using individual participant data (IPD) identified from a systematic review of randomised controlled trials (RCTs).

• IRAS ID

  284429

• Contact name

  David Steel

• Contact email

  david.steel@ncl.ac.uk

• Sponsor organisation

  Newcastle University

• Duration of Study in the UK

  1 years, months, days

• Research summary

  Macular holes are an important and blinding retinal disease. Surgery can improve vision but the degree of improvement is variable. The effect of duration of symptoms on the results of surgery is unclear based on current evidence. This is important as macular hole surgery is currently not prioritised. We aim to carry out a meta-analysis of individual patient data from high quality prospective trials of patients undergoing macular hole surgery to investigate this question further.

• REC name

  London - London Bridge Research Ethics Committee

• REC reference

  20/PR/0406

• Date of REC Opinion

  15 Sep 2020

• REC opinion

  Favourable Opinion