SURVIVE-SS
Research type
Research Study
Full title
Characterising cardiac involvement in severe sepsis: a multimodal imaging study (SURVIVE-SS)
IRAS ID
335206
Contact name
Jayanth Arnold
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
0 years, 11 months, 0 days
Research summary
Sepsis is a leading cause of death worldwide, and the principal cause of morbidity and mortality in intensive care units in the UK. Involvement of the heart in severe sepsis is frequent and makes the course of the illness more severe. Currently, we have a poor understanding of the mechanisms of disease when the heart is involved. A better understanding of the disease process will enable us to develop better treatments and improve clinical outcomes.
The main objective of this study is to demonstrate the feasibility of undertaking a multi-modality serial imaging study in patients with severe sepsis, involving three different types of scans (ultrasound, computed tomography (or CT) and magnetic resonance imaging (or MRI)) to obtain detailed information about a person’s heart including why there may be a problem with their heart function. It is hoped that this will lead to a better understanding of the disease processes, help to plan future research studies and hopefully lead to the development of new treatments.
This pilot study will assess (A) heart volumes and function, (B) injury to the heart, and (C) the blood supply to the heart. A pilot observational phase (single-centre, n=3) will first test the feasibility of undertaking study procedures in acutely unwell adult patients with severe sepsis. If feasibility is confirmed, this work will pave the way for a larger, definitive multi-centre study to characterise the mechanisms of cardiac disease in severe sepsis (subject to future funding).
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
24/LO/0095
Date of REC Opinion
22 Mar 2024
REC opinion
Further Information Favourable Opinion