SURVIVE-MI
Research type
Research Study
Full title
SUdden death Risk eValuatIon and VulnErability post-Myocardial Infarction
IRAS ID
355700
Contact name
G. Andre Ng
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Background: Sudden Cardiac Death (SCD) in many cases can be avoided by an implantable cardioverter defibrillator (ICD). One of the largest groups at risk of SCD are people who have had a myocardial infarction (MI). The crucial issue is the risk stratification of these people to decide who would benefit from an ICD and who would not. This is because there is an incomplete understanding of what risk factors are associated with SCD.
Aims: To study SCD risk marker performance following MI, further the physiological and psycho-social understanding of SCD risk factors, study the generation of SCD risk markers using different methods within different populations.
Methods: This prospective study will enrol participants in an exercise electrocardiogram (ECG), echocardiogram and a 24-hour ambulatory ECG regimen following MI to assess cardiac electrophysiological parameters and compare them to healthy controls. Participants will also complete health-based questionnaires at the same time point, followed by a subgroup qualitative focus group. Analysis will use a mixed methods approach.
Impact: This project will also explore the interplay between previously unexamined psychological and electrophysiological aberrancies following MI. It aims to build on previous work to create a risk stratification measure for SCD following MI with higher accuracy than current approaches, providing evidence to support a large-scale trial.
REC name
London - South East Research Ethics Committee
REC reference
26/LO/0063
Date of REC Opinion
3 Feb 2026
REC opinion
Further Information Favourable Opinion