Survival of children born with congenital heart disease
Research type
Research Study
Full title
Survival and predictors of survival in children born with congenital heart disease
IRAS ID
117092
Contact name
Judith Rankin
Contact email
Sponsor organisation
Newcastle University
Research summary
The overall aim of the proposed project is to match death registrations held by the Office for National Statistics (ONS) to high quality population-based congenital anomaly data collected by the British Isles Network of Congenital Anomaly Registers (BINOCAR) on children born with a congenital heart disease (CHD). Using the matched data we will describe the one, five, ten and twenty year survival of children born with a CHD. We will report survival for all CHDs combined and by subtype (e.g. Tetralogy of Fallot, ventricular septal defect etc), which differ by severity. Additionally we will examine predictors of survival using demographic data collected for each case by the BINOCARs including: maternal age, antenatal diagnosis (diagnosed and undiagnosed), index of multiple deprivation, infant sex, birth weight, gestational age at delivery, associated anomalies, number of fetuses, ethnicity and year of delivery. For one register (the Northern Congenital Abnormality Survey) we will also investigate the impact of surgery on survival. Lastly, we will use the data to predict survival in children with CHDs in the future, assuming current and past trends continue.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
13/NE/0188
Date of REC Opinion
1 Aug 2013
REC opinion
Favourable Opinion