Survey to examine the trajectory of mood against activity in IBD v1.0
Research type
Research Study
Full title
A Survey to Determine the Trajectory of Depression and Anxiety in Patients with Inflammatory Bowel Disease and the Relationship to Clinical Activity
IRAS ID
272683
Contact name
Alex Ford
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
3 years, 5 months, 10 days
Research summary
Crohn's disease and ulcerative colitis are conditions that cause inflammation in the bowel. They result in symptoms of abdominal pain and an alteration in bowel habit. During periods when these symptoms flare up, increased inflammation is often detected in the blood stream and may also affect other areas of the body.
We know that rates of depression and anxiety are higher in patients with Crohn's disease and ulcerative colitis compared with the general population. Results of previous studies suggest that patients who experience more flares of their inflammatory bowel disease are more likely to have low mood for a longer period of time. This may also be because there is a link between inflammatory bowel disease and poor mood. It is therefore possible that treatments aimed at improving mood may also have an impact on disease outcomes in Crohn's disease and ulcerative colitis.
Using a set of online questionnaires, we want to see if changes in mood over time have any influence on Crohn's disease and ulcerative colitis activity. If consistently worse mood is associated with poorer outcomes in inflammatory bowel disease, this may affect how we manage these conditions in the future.
REC name
Wales REC 7
REC reference
20/WA/0044
Date of REC Opinion
3 Feb 2020
REC opinion
Favourable Opinion